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Esta selectividad es una de las razones del inters experimental por incluir Ipamorelina en el blend
QA accumulation is associated with brain inflammation and cell death, and patients with advanced CKD exhibit elevated plasma KYN metabolites and QA, which uniquely correlate with fatigue and reduced quality of life (Saliba et al., 2024), supporting the role of gut-derived KYN metabolites in linking CKD to neuroinflammation
Outcome Focus: The trials were designed primarily to assess weight loss efficacy, with safety as a secondary outcome
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