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Abbreviations AAP: American Academy of Pediatrics AC: Abdominal Circumference ADA: American Diabetes Association ALT: Alanine Aminotransferase AST: Aspartate Aminotransferase ASCVD: Atherosclerotic Cardiovascular Disease AOM: Anti-Obesity Medication AOMs: Anti-Obesity Medications BMD: Bone Mineral Density BMI: Body Mass Index BP: Blood Pressure CPCG: Canadian Clinical Practice Guidelines CKD: Chronic Kidney Disease CRP: C-Reactive Protein DBP: Diastolic Blood Pressure eGFR: Estimated Glomerular Filtration Rate EASO: European Association for the Study of Obesity FFM: Fat-Free Mass GGT: Gamma-Glutamyl Transferase GI: Gastrointestinal GLP-1: Glucagon-like Peptide-1 GIP: Glucose-dependent Insulinotropic Polypeptide HbA1c: Hemoglobin A1c HF: Heart Failure HFpEF: Heart Failure with Preserved Ejection Fraction HOMA-IR: HOmeostatic Model Assessment for Insulin Resistance HRQoL: Health-Related Quality of Life ICER: incremental cost-effectiveness ratio LDL: Low-Density Lipoprotein MASLD: Metabolic Dysfunction-Associated Steatotic Liver Disease MASH: Metabolic Dysfunction-Associated Steatohepatitis MACE: Major Adverse Cardiovascular Events MHO: Metabolically Healthy Obese MUO: Metabolically Unhealthy Obese PA: Physical Activity PCOS: Polycystic Ovary Syndrome QALYs: Quality-adjusted life years QoL: Quality of Life RCT: Randomized Controlled Trial RMR: Resting Metabolic Rate SBP: Systolic Blood Pressure T1D: Type 1 Diabetes T2D: Type 2 Diabetes WC: Waist Circumference WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index References Bray GA, Kim KK, Wilding JPH, World Obesity Federation (2017) Obesity: a chronic relapsing progressive disease process

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Because GLP-1 receptor agonists are believed to be metabolized in various areas throughout the body and not specifically in the liver, 35 no significant variations were expected within any of the groups

The Problem Most patients do not just need a vial