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Francis GL, Ross M, Ballard FJ, Milner SJ, Senn C, McNeil KA, Wallace JC, King R, Wells JR (1992) Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency

doi: 10.1136/emermed-2020-209980 357

A reduction in the mRNA level of inflammatory mediators (iNOS, IL-6, IFN-, and TNF-) and increased expression of HSP 70 and 90 and antioxidant proteins such as HO-1, NQO-1, glutathione reductase, glutathione peroxidase 2, and GST-pi were observed (Park et al., 2020)

Whole-Body and Metabolic Causes Diabetes-related neuropathy High blood sugar damages nerves over time, leading to tingling, numbness, and burning in hands and feet (often stocking-glove distribution)