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the relevance of these findings to human risk remains uncertain and has not been definitively established in clinical trials or epidemiologic studies (Mller et al., 2019)

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doi: 10.1210/jc.2012-3855 33 RonnJJensenEPWewer AlbrechtsenNJHolstJJSorensenCM

Dysfunctional brain insulin signaling has been shown using blood-neuron-derived extracellular vesicles, whereby PD patients display altered IRS1 phosphorylation, which is further correlated with tremor severity [158]