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Studies now show conclusively that cataracts, glaucoma, and macular degeneration are always accompanied by, and significantly worsened by, on-going and un-neutralised oxidative stress in the eye 13

(This also explains why aqueous-solubility models outperformed intrinsic-solubility models on the intrinsic-solubility test sets.) Nevertheless, using to predict pH-dependent solubility gives a good qualitative match with experiment, excepting cases where ion aggregation leads to lower-than-expected solubility

BAC water is often chosen because it allows multi-use convenience across several doses