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Dihexa, with its combined N-hexanoic-Tyr-Ile-(6) aminohexanoic amide structure, exhibited a significantly extended half-life of 335.5 9.5 min, confirming that both N- and C-terminal modifications are effective strategies for improving metabolic stability [1]

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Treatment of GLP-1-associated nausea typically starts with dietary modification, including eating smaller portions of food, eating smaller more frequent meals, avoiding foods high in fiber and fat, and increasing fluid intake with meals [7]