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Conditions associated with MCAS include: Chronic Lyme disease Fibromyalgia Autism Hypercoagulation ME/CFS (chronic fatigue syndrome) Irritable bowel syndrome (IBS) and small intestine bacterial overgrowth (SIBO) POTS/Dysautonomia Hypermobile Ehlers-Danlos syndrome Multiple chemical sensitivity Autoimmune conditions Mast Cell Activation Syndrome in Digestive Disorders Mast cells are highly concentrated in the gastrointestinal tract to protect humans from any foreign invaders they may swallow

Vitamin E provides antioxidant protection and supports skin repair

The combination may either exacerbate diarrhoea or help manage constipation, depending on the formulation and individual response

Glucagon-Like Peptide I and glucose-dependent insulinotropic polypeptide stimulate Ca2+-induced secretion in rat -Cells by a protein kinase A-mediated mechanism