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However, in DW, macrophage polarization is arrested in the M1 state, leading to chronic inflammation and impaired healing (Shao et al., 2025

Other medications worth flagging include nitroglycerin (glutathione may blunt its vasodilating effect), certain antipsychotics, and long term proton pump inhibitors, which reduce stomach acid and impair absorption of cysteine precursors

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Low insulin disinhibits lipolysis (fat breakdown), shifting the metabolic preference toward burning fat for fuel