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Together with a small quantity in the ovary and gastrointestinal (GI) tract, its significant amount is found in the bone marrow, cerebral fluid, and bile juice

Methods Animal experiment Male SHR and WKY rats, aged 2, 3, 4, 6, 8, 10, 12 and 16 weeks, were obtained from the Laboratory Animals Research Unit of Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia and housed at room temperature with a 1212 h lightdark cycle (06001800 hours), and with access ad libitum to food and water throughout the experimental period

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