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Disruptions in the NVU, leading to BBB dysfunction and reduced CBF, are early events in various neurodegenerative diseases, including AD, PD, and ALS [85]

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In quelli pi seri, invece, il deficit energetico potrebbe causare nei neonati encefalopatia ed epilessia, mentre negli adolescenti e negli adulti battiti irregolari, convulsioni, problemi respiratori, miopatia e morte improvvisa negli anziani