Common metabolic pathways involved in ferroptosis, such as (seleno) thiol metabolism, mitochondrial respiration iron handling, mevalonate pathway, and fatty acid metabolism, directly impact cellular sensitivity to lipid peroxidation and ferroptosis
Oxidative Stress from Even-Electron Metal-Thiol Conjugates: A Case for Mercury Oxidative stress is loosely defined as a condition of impaired physiological balance between the energy-producing oxidative metabolism of nutritional carbon substrates, oxygen supply to the cells and the concentrations of antioxidant compounds, which is reflected at the biochemical level into an imbalance of the dynamic physiological ratio of oxidizing and of reducing processes and related molecules [11]
Biol Trace Elem Res 199(10):36473657 Ferguson LR, Karunasinghe N, Zhu S, Wang AH (2012) Selenium and its role in the maintenance of genomic stability
chronic age-related diseases such as cataract, macular degeneration, glaucoma and hearing loss