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Catalpol enhances the expression of brain-derived neurotrophic factor (BDNF) by upregulating the phosphorylation of cAMP response element-binding protein (CREB), improving the survival of -amyloid (A)-damaged SH-SY5Y neuroblastoma cells, and providing a theoretical basis for its neuroprotective effects in Alzheimers disease ( In summary, catalpol has demonstrated robust in vitro and in vivo neuroprotective activity against various neurological conditions, including those induced by rotenone, OGD/reoxygenation in SH-SY5Y cells, lead in PC12 cells, LPS in BV-2 cells, traumatic brain injury, spinal cord injury, cognitive impairment, and Alzheimers disease

Moreover, the vitamin-D3 pathway was identified as one of the major regulators of cathelicidins [179, 180]

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Coupled electrochemical half cells have the thermodynamic properties of other coupled chemical reactions