Gomar et al
Correlation analysis To elucidate the potential mechanisms by which FGJ ameliorates type II diabetes, a comprehensive correlation analysis was performed, integrating data on juice composition, glycemic indices, lipid metabolism, oxidative stress markers, gut microbiota, and SCFAs (Fig
56 Our findings build on two previously reported PDAC-specific characteristics, namely, 1st RAS signaling driving glutamine metabolism for ROS homeostasis 22,50,51 and 2nd mitochondrial dependency upon genetic loss of the KRAS oncogene, 41 and connect them with a more generally described cancer cell state associated with therapy resistance, characterized by a dependence on lipid peroxidation defense pathways
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