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The results were consistent: Trunk fat reduction: Tesamorelin-treated patients showed statistically significant reductions in trunk fat versus placebo at 26 weeks.[1] VAT reduction: Using cross-sectional CT imaging, tesamorelin produced approximately 1520% reductions in visceral adipose tissue compared to placebo.[1,2] Triglyceride improvement: Alongside fat reduction, tesamorelin improved triglyceride levels a key marker in metabolic syndrome.[2] Tesamorelin IGF-1 elevation: Treatment reliably elevated IGF-1 levels toward age-appropriate norms, confirming successful GH-axis stimulation.[1] These reductions occurred without dietary caloric restriction being mandated
GLP1R expression in prostate cancer cells was associated with increased expression of Notch signaling, which has previously been implicated in neuroendocrine differentiation and subsequent therapeutic resistance (45, 46, 54)
Increased testicular insulin-like growth factor 1 is associated with gonadal activation by recombinant growth hormone in immature rats
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