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The Journal of Immunology 181, 680689 (2008)

Serotonin connects to reward pathways by playing a regulatory role in the brains reward system, where it interacts with dopamine to influence behaviors tied to pleasure and reinforcement , as explained in a study by Harvard Brain Science Initiative titled Exploring How Serotonin and Dopamine Interact. While dopamine directly activates the reward pathway, triggering sensations of pleasure when we engage in rewarding activities, serotonin helps to modulate this pathway, maintaining balance

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Nguyen et al., 2023)