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Clinical trials show average weight loss of 15-22.5% of body weight over 72 weeks with tirzepatide alone

The exposome encompasses diet, toxins, stress, and other environmental influences that regulate gene expression through epigenetic mechanisms. These epi- meaning "above" genetic factors can turn genes "on or off" without changing DNA, affecting metabolism across generations

Quality assessment of the included studies The Systematic Review Centre for Laboratory Animal Experiments (SYRCLE) tool was used to determine the "risk of bias" in the included studies (Figure 2) []

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