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Dizziness or Fatigue : A few individuals experience dizziness or general fatigue after starting therapy, likely due to the body adjusting to the peptide

A phase II study is currently investigating the neuroprotective effects of injectable semaglutide in 270 Parkinsons patients in a double-blinded, placebo-controlled design (NCT03659682)

In colorectal cancer, IGF-2 secreted by cancer-associated fibroblasts binds to IGF-1R on cancer cells to activate the PI3K/AKT/mTOR and Hippo-YAP1 signaling pathways to promote cancer cell proliferation, migration and invasion