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4.5 Mitophagy and diabetes complications Diabetes mellitus is a type of metabolic disease caused by abnormal lipid metabolism or insulin dysfunction, and persistent chronic elevation of blood glucose and long-term metabolic disorders can damage tissues and organs throughout the body, leading to complications such as diabetic kidney disease (DKD), diabetic cardiomyopathy (DCM), and diabetic muscle atrophy (Wen et al., 2023)

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After lumbar puncture subjects were informed strictly to rest in comfortable positions and to avoid straining actions and Valsalva maneuvers such as lifting luggage for 24 h before discharge