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(34) Experimental and clinical studies demonstrate that GLP-1RAs reduce the production of proinflammatory cytokines (e.g., TNF- , IL-6, Interleukin-1 - IL-1) and chemokines (e.g., Monocyte Chemoattractant Protein-1 - MCP-1, CXCL10), while increasing anti-inflammatory cytokines such as Interleukin-10 (IL-10)

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These early adjustments enable plants to handle biotic and abiotic stresses, as reflected in reduced TYLCV incidence during the resistance period over eight weeks, linked to upregulated genes involved in plant-pathogen interactions and secondary metabolism, reinforcing sulfurs role in plant defenses 24,25