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The following themes summarize key areas of ongoing investigation: N NMT, NAD , and Energy Metabolism NNMT catalyzes the methylation of nicotinamide, diverting potential NAD precursors into alternative metabolites

More recently, the A946T variant alone was confirmed to lead to increased basal type I IFN activity in reporter cell lines due to increased MDA5 ATPase activity, which may enhance filament formation on dsRNA and downstream signaling (115)

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Studies suggest it can block the NF-B pathway and reduce inflammatory cytokines like TNF- and IL-6 without causing skin darkening, making it a potentially safe option for systemic use