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MDMA metabolic clearance accounts for about 75% of plasma clearance and 30% of its metabolism is regulated by CYP2D6 (de la Torre et al., MDMA CYP2D6 mechanism-based inhibition and the phenocopying phenomenon As previously stated, whilst MDMA is metabolized by CYP2D6 it is also a potent MBI of the enzyme (de la Torre et al., de novo synthesis (Liston et al., MDMA and CYP2D6 pharmacogenetics Most research evaluating the potential impact of CYP2D6 pharmacogenetics in MDMA pharmacology has been focused on acute effects

Am J Bioeth

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This research showed that GSH supplementation of amino acids (including L-glycine) and micronutrients (including vitamin C, vitamin E, and magnesium), as well as specific dietary patterns (vegetarian, the Mediterranean diet, and the DASH diet) had the potential to raise glutathione concentrations, which in turn slowed the rate of tissue deterioration