(2016) found that acute fluoxetine administration in prepubertal female rats resulted in increased estradiol concentrations, whereas subchronic administration led to increased serotonin concentrations in the ovaries, a decrease in the number of ovulations, a greater number of atretic follicles, and oocyte fragmentation
Moreover, flavonoids can also upregulate the activity of antioxidant enzymes, thereby enhancing the antioxidant defense system ( Research has shown that 7,8-dihydroxyflavone (7,8-DHF) can alleviate SZ-like symptoms by effectively mimicing the effect of brain-derived neurotrophic factor (BDNF) in the brain (Emili et al., 2022) and downstream Phospholipase C (PLC), AKT, and ERK1/2 signaling pathways
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In SURMOUNT-1, 72 weeks of tirzepatide induced mean WL of 1622.5% in people without diabetes compared to 2.4% with placebo, with no sign of the weight plateauing, suggesting that there may be further WL with long-term use [46]
