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These effects are characteristic actions mediated through GCG receptor activation by dual or triple agonists incorporating glucagon receptor activity (e.g., mazdutide, retatrutide )

Several medications have entered phase 2 or 3 of clinical trials for PWS patients ( and this therapeutic approach of appetite modulation via the hypothalamus could provide promising results not only in PWS patients, but also for patients with other types of hypothalamic obesity

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Altogether, these results demonstrate that a selective antibiotic strategy enabled us to identify the specific bacterial taxa associated with GLP-1 levels