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The effective mRNA treatments should accurately target specific cells, tissues, or organs, rendering transport efficiency, tissue bioavailability, half-life in bloodstream, and LNP performance significant limiting factors, particularly beyond the liver, which is more readily targeted

Explain to patients and caregivers that effects of opioid overdose reversal agents like naloxone and nalmefene are temporary, and that they must call 911 or get emergency medical help right away in all cases of known or suspected opioid overdose, even if an opioid overdose reversal agent is administered (see OVERDOSAGE)

2013 Aug;10(8):473-86

Reconstitute only what you can use within the stability window, or plan to aliquot and freeze the excess immediately