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Sunscreen use is essential during the day, as tretinoin increases sensitivity to sunlight

This explains the different side effect profiles

Adams JB, Audhya T, McDonough-Means S, Rubin RA, Quig D, Geis E, Lee W (2011) Effect of a vitamin/mineral supplement on children and adults with autism

B12-deficiency anemia can cause further complications, such as: difficulty walking uncontrollable muscle movements changes in smell or taste unintentional weight loss bleeding infection permanent brain or nerve damage B12 deficiency and anemia There are Diet: A person whose diet does not contain enough B12 can develop a deficiency after around 3 years, after which the body may begin to run out of stored B12