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Chang L, Sultan S, Lembo A, Verne GN, Smalley W, Heidelbaugh JJ

6 CARDIOVASCULAR EVENTS: 7 GLP drugs impact coagulation factors and platelets by impairing thromboxane-dependent platelet aggregation and prolonging bleeding time

However, several important considerations argue for caution in extending orforglipron to pediatric populations

Estrogen Exposure and Adipose-Driven Hormonal Modulation Because adipose tissue produces estrogen via aromatase, reductions in visceral fat can lower peripheral estrogen levels in some individuals