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110 Macrophage polarization refers to the process by which macrophages are stimulated by different signals in various microenvironments to change their phenotype and function

It suppresses ECM degradation, counteracts RSL3 mediated inhibition of GPX4, increases intracellular GSH levels and the GSH/GSSG ratio, reduces MDA content, and inhibits activation of the MAPK/NF-KB pathways, thereby protecting chondrocytes from ferroptosis (156)

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