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Clinical Data from Competitor Agents: Strengths and Limitations of CT-388 in Light of Competitor Data: Strengths: - CT-388 demonstrates a positive safety and tolerability profile with manageable GI-related side effects that are consistent with the incretin class.- CT-388 has shown statistically significant weight loss across cohorts in its Phase 1/2 trial, with the highest dose cohort (Cohort 8) averaging an 8.4% weight loss at four weeks.- The prolonged half-life of CT-388 suggests the potential for once-weekly dosing, which could bolster adherence compared to therapies requiring more frequent administration.- Weight loss with CT-388 is accompanied by improvements in metabolic parameters such as waist circumference and HOMA-IR, indicating a potential benefit for patients with obesity and associated comorbidities

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The recommended 5-Amino-1MQ dosage for subcutaneous (subQ) injection ranges from 150-500 mcg daily

J.ZhangZ.LiK.LiB.ZhangW.et al (2012)