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Across the six published trials, the most common adverse events were headache, mild gastrointestinal effects (diarrhea, flatulence, nausea), nasopharyngitis, fatigue, dizziness, and mild injection-site reactions

A question remains as to whether this therapy is effective in patients with existing HFpEF or if its primary benefit lies in impacting risk factors and associated cardiovascular diseases that contribute to the development of HFpEF

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Medical evidence suggests these effects stem from multiple factors, including hormonal changes, brain reward systems, and physical responses to the medication