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At the same time, bile acid signaling pathways, including the farnesoid X receptor (FXR)FGF15 and TGR5glucagon-like peptide-1(GLP-1) axes, are disrupted, further promoting hepatic lipid accumulation and immune dysregulation

This term refers to a specific shape or appearance of the upper lip that resembles an upside-down letter V- a groove or depression that extends downward towards the center of the upper lip

So, it is disappointing that the EPIC Study's authors do not go into any details about those 8.4% of dogs being treated with pimobendan and which died cardiac-related deaths prior to CHF

Matsumoto N, Yoshizawa H, Kagamu H, et al