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Recent work from our group demonstrated that the endogenous agonist for GLP-1R, GLP-1 (7-36), activates members from all G protein families at the plasma membrane 5

Nevertheless, GLP-1 presented a rather ephemeral circulatory half-life, lasting a mere 12 min, due to the rapid enzymatic degradation by dipeptidyl peptidase IV (DPP-4), which markedly limits its biological efficacy [3,4,5]

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