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Recent studies have also explored its potential in reducing pain and inflammation in the digestive tract, indicating its potential as a therapy for inflammatory bowel disease and irritable bowel syndrome

What the Science Says: Clinical Evidence So Far Clinical research on peptide therapy for hair growth is still relatively new, but the early signs are promising

Eric Verdin, in a review published in Science (2015), documented NAD+ depletion across aging tissues and its downstream effects on sirtuin enzyme activity, PARP-mediated DNA repair, and mitochondrial function

Because SAM is also required for many other methylation reactions, including gene-expression regulation, high NNMT activity draws heavily on SAM and is associated in studies with reduced NAD, a coenzyme central to cellular energy production