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These regions encompass TM5 (TransMembrane helix 5), L0 (or ICL3 (Intracellular Loop 3)), TM6-TM7, ECL4 (Extracellular Loop 4), TM10-TM11, L1 (or ICL6), TM12-ECL7, and TM16-TM17

reduction of microcirculation in the brain (Hassan et al, 2004)

Uric acid nephropathy is caused by the deposition of uric acid crystals in the collecting tubules, renal pelvis or the ureter and results in impaired urine flow

7.4 L-carnitine L-Carnitine (3-Hydroxy-4-(trimethylazaniumyl) butanoate) is a biological compound that is ubiquitous in mammalian tissues and fluids where it is required for -oxidation of fatty acids by facilitating their transport in the form of acyl-carnitine esters across the mitochondrial inner membrane (206)