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Discussion Findings from this investigation indicate that eight weeks of supplementation with ALCA results in an increase in resting nitrate/nitrite in pre-diabetics, but does not promote significant changes in other metabolic or oxidative stress variables measured at rest or post meal

4.3.3 Context-dependent dual role of butyrate in modulating ferroptosis via multiple signaling pathways The direct chondroprotective effects of butyrate in OA are well understood and mainly mediated by the attenuation of inflammation and matrix break down, both of which inhibit cartilage catabolism (Han et al., 2025)

Adding a second or third compound without a clear clinical reason increases cost and complexity and may make side effects harder to identify

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