It is possible that it may be slightly uncomfortable for some very sensitive people.
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A GLP-1 blocker acts by inhibiting the GLP-1 receptor, which modulates the downstream inflammatory pathways linked to: cytokine production immune system activation oxidative stress inflammatory signaling in tissues such as the liver, fat cells, and gut In low doses, blocking GLP-1 receptors appears to influence the immune system without significantly interfering with glucose control which is why this approach is being studied specifically for inflammation rather than metabolic disease
Similarly, GWS has been associated with elevated oxidative stress (Shetty et al., 2017) with melatonin being shown to improve brain function in the GWS model, through modulation of oxidative stress (Madhu et al., 2021)
