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It enrolled adults with a body mass index of 30 or greater, or 27 or greater with at least one weight-related comorbidity, and randomized them across multiple retatrutide dose arms (1 mg, 4 mg, 8 mg, and 12 mg weekly) versus placebo

Besides berberine, other botanicals including citrus fruit extracts, green tea, saffron, and coffee bean extract have been studied for their potential role in GLP-1 production with mixed results

For patients who have resolved their diabetes using a GLP-1 for weight loss and glucose control, they may have a return of their type 2 diabetes, says Lofton, who adds that it varies from person to person