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Furthermore, SAE remains notably underdiagnosed and undertreated, and survivors often develop persistent long-term neurocognitive sequelae, including hippocampus-dependent memory impairment, psychiatric disorders and functional disability, which severely impact quality of life ( Oxidative stress is central to SAE pathogenesis, driven by an imbalance between excessive reactive oxygen species (ROS) production and impaired antioxidant defense systems (Yan et al., 2022)
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Shao X, Johnson JE, Richardson JA, Hiesberger T, Igarashi P
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