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Adjuvant Endocrine Therapy for Women With Hormone Receptor-Positive Breast Cancer: ASCO Clinical Practice Guideline Focused Update

Why it matters: Short telomeres are associated with cellular senescence (aging) and disease

Since SCEs are typically absent in tightly packed heterochromatic regions, the increase in SCE frequency indicates that Livagen decondenses chromatin, rendering previously repressed euchromatic regions accessible for transcription and recombination