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Many of the functional studies on SOCS proteins have focused on SOCS1 and SOCS3
There is a big difference between hormetic cortisol spikes (exercise, fasting, cold) and chronic cortisol drip (financial stress, bad sleep, anxiety) Hormetic stress: quick spike then shutoff, changes receptor density in a beneficial direction
10.1001/archpedi.161.4.334 36 CroenL
Studies suggest that Sermorelin may mimic endogenous hypothalamic signals that trigger growth hormone synthesis, while Ipamorelin may activate complementary receptor pathways that modulate hormone secretion dynamics
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