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Janice Jin Hwang, the division chief of endocrinology and metabolism at the University of North Carolina School of Medicine tells the New York Times

Reproductive and Metabolic Hormones Certain peptides like kisspeptin analogues act at the hypothalamic level to normalize release of follicle stimulating hormone and luteinizing hormone, indirectly influencing testosterone, estrogen, and ovulation patterns

[3] The mechanism driving muscle loss during prolonged caloric restriction involves increased muscle proteolysis rather than suppressed protein synthesis, [4] meaning the body actively breaks down existing muscle tissue to meet energy demands, and this process accelerates in hormone-deficient states

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