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doi: 10.1371/journal.pone.0086377 127 SuddekGM

its depletion therefore precipitates ferroptosis ( + , prevents copper binding to lipoylated proteins and restrains cuproptosis (64) demonstrated that disulfiramcopper (DSF/Cu) blocks ubiquitin-dependent degradation of the cystine transporter xCT, leading to GSH exhaustion, lipid-peroxide accumulation and compensatory xCT up-regulation