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Recently accelerated approval was given to two PPARs, namely Seladelpar and Elafibranor, for use in non-responders to UDCA as second line therapy ( Figure 4 )

doi: 10.1016/j.arr.2005.02.005

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found that selenium deficiency in RAW 264.7 macrophages increases oxidative stress and enhances iNOS expression and NO production through heightened NF-B activation, suggesting seleniums key role in regulating inflammatory responses (Prabhu et al., 2002)