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Comparing GLP-1 Receptor Agonists with Other Diabetes Treatments When considering treatment options for type 2 diabetes, GLP-1 receptor agonists offer distinct advantages compared with other glucose-lowering therapies, though the optimal choice depends on individual patient characteristics, preferences, and clinical circumstances
Among dual agonists, tirzepatide at 15 mg weekly (Zepbound) produced 20% to 22% mean weight loss
Fact: Formulation and delivery are the biggest differentiators
Nevertheless, despite increased levels of GLP-1, TG excursion was not reduced, and was actually transiently increased, in HFD-fed mice after gut-selective sitagliptin (Figure 5B)
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