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According to our data, SGLT-2 inhibitors show the highest probability to be superior to GLP-1RA and DPP-4 inhibitors in terms of HHF and the composite renal outcome, while GLP1-RA are superior to DPP-4 inhibitors for both outcomes

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With orforglipron offering additional advantages such as the elimination of strict pre-dosing requirements, potential lower cost, and easier storage, it will be important to see whether these features lead to even greater adherence, says Priya Jaisinghani, a diabetes and obesity medicine specialist at NYU Langone