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[86] found that semaglutide, as a GLP-1 analog, can directly act on fat cells, increase the expression of thermogenic genes for browning phenotype maintenance, improve the expression of UCP1, mitochondrial biosynthesis and thermogenic marker, thereby contributing to weight loss

Post-mortem cortical tissue from people with ASDshows significantly reduced MET protein levels, accompanied by dysregulation of HGF-MET co-expression, suggesting disrupted signaling pathways (117)

Later randomized trials extended the human evidence to reduction of liver fat in HIV-associated fatty liver disease

Research demonstrates KPV reduces proinflammatory cytokines in models of inflammatory bowel disease and systemic inflammation [3]