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In the Boyden chamber assay, TB4 stimulated keratinocyte migration 23-fold over medium alone after just 45 hours, with as little as 10 pg of TB4 sufficient to produce a potent stimulatory response

Comment: Several commenters cautioned CMS to avoid defaulting to extensions in cases where broader relief is warranted and ensure reporting extensions are not disproportionately utilized in place of exceptions

These results suggest that the respective macrocycles probably bind different regions of the Met ectodomain, requiring an adequate length of cross-linker for their effective dimerization of Met

These numbers assume consistent room temperature around 25 degrees Celsius