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It is important to note that only the oxidized forms of NAD (NAD + and NADP + ) were included in the comparative validation due to instability of reduced forms (NADH and NADPH) in MS analyses

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147 Leptin binds to the leptin receptor (LepRb) and activates JAK2/STAT3 pathway to decrease body weight and normalizes blood glucose concentration, meanwhile, JAK2 stimulates the phosphorylation of insulin receptor substrate (IRS1/2), then activates PI3K/Akt pathway and directly affect insulin action