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Notably, the corresponding mechanistic relationships remain to be elucidated

and Reynolds JC et al., "MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis," Nature Communications, 2021

In addition, GLP-1R agonists have been observed to enhance the health of endothelial cells in the brain, promoting vascular remodeling, which may further support cognitive function