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The PIONEER 3 study (Effect of Additional Oral Semaglutide vs Sitagliptin on Glycated Hemoglobin in Adults With Type 2 Diabetes Uncontrolled With Metformin Alone or With Sulfonylurea: The PIONEER 3 Randomized Clinical Trial), consisting of 1864 subjects, tested the effectiveness of Rybelsus to Januvia (another DPP-4 inhibitor)

A brand-name Ozempic pen carries an expiration date that might be two years from manufacture when unopened