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Preclinical models indicate that GLP-1 receptor activation can influence the gut-brain axis as well as the hypothalamic-pituitary-adrenal (HPA) axis, with possible implications for stress regulation and energy homeostasis[11]

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In the retatrutide Phase 2 trial, high-sensitivity CRP fell alongside body weight [1], which mechanistically predicts improved central androgen signaling even before peripheral hormone levels are measured